Reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol
Other name(s): ubiquinone reductase; coenzyme Q reductase; dihydronicotinamide adenine dinucleotide-coenzyme Q reductase; DPNH-coenzyme Q reductase; DPNH-ubiquinone reductase; NADH-coenzyme Q oxidoreductase; NADH-coenzyme Q reductase; NADH-CoQ oxidoreductase; NADH-CoQ reductase; NADH-ubiquinone reductase; NADH-ubiquinone oxidoreductase; reduced nicotinamide adenine dinucleotide-coenzyme Q reductase; NADH-Q6 oxidoreductase; electron transfer complex I; NADH2 dehydrogenase (ubiquinone)
Systematic name: NADH:ubiquinone oxidoreductase
Comments: A flavoprotein (FAD). Occurs in mitochondria of yeast and plants, and in aerobic bacteria. Has low activity with NADPH.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number:
References:
1. Moller, I.M, and Palmer, J.M. Direct evidence for the presence of a rotenone-resistant NADH dehydrogenase on the inner surface of plant mitochondria. Physiologia Plantarum 54 (1982) 267-274.
2. de Vries, S. and Grivell, L.A. Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae. Eur. J. Biochem. 176 (1988) 377-384. [PMID: 3138118]
3. Kerscher, S.J., Okun, J.G. and Brandt, U. A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica. J. Cell Sci. 112 ( Pt 14) (1999) 2347-2354. [PMID: 10381390]
4. Rasmusson, A.G., Soole, K.L. and Elthon, T.E. Alternative NAD(P)H dehydrogenases of plant mitochondria. Annu. Rev. Plant Biol. 55 (2004) 23-39. [PMID: 15725055]