IUBMB Enzyme Nomenclature

EC 1.6.99.3

Accepted name: NADH dehydrogenase

Reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor

Other name(s): cytochrome c reductase; type 1 dehydrogenase; β-NADH dehydrogenase dinucleotide; diaphorase; dihydrocodehydrogenase I dehydrogenase; dihydronicotinamide adenine dinucleotide dehydrogenase; diphosphopyridine diaphorase; DPNH diaphorase; NADH diaphorase; NADH hydrogenase; NADH oxidoreductase; NADH-menadione oxidoreductase; reduced diphosphopyridine nucleotide diaphorase; NADH:cytochrome c oxidoreductase; NADH2 dehydrogenase; NADH:(acceptor) oxidoreductase

Systematic name: NADH:acceptor oxidoreductase

Comments: A flavoprotein containing iron-sulfur centres. After preparations have been subjected to certain treatments, cytochrome c may act as an acceptor. Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. Formerly EC 1.6.2.1; present in a mitochondrial complex as EC 1.6.5.3 NADH dehydrogenase (ubiquinone).

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9079-67-8

References:

1. Adachi, K. and Okuyama, T. Study on the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes. I. Crystallization and properties of the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes. Biochim. Biophys. Acta 268 (1972) 629-637. [PMID: 4402556]

2. Hatefi, Y., Ragan, C.I. and Galante, Y.M. The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system. In: Martonosi, A.N. (Ed.), The Enzymes of Biological Membranes, 2nd ed., vol. 4, Wiley, New York, 1985, p. 1-70.

3. Hochstein, L.I. and Dalton, B.P. Studies of a halophilic NADH dehydrogenase. I. Purification and properties of the enzyme. Biochim. Biophys. Acta 302 (1973) 216-228. [PMID: 4144655]

4. Kaniuga, Z. The transformation of mitochondrial NADH dehydrogenase into NADH:Cytochrome c oxidoreductase. Biochim. Biophys. Acta 73 (1963) 550-564.

[EC 1.6.99.3 created 1961 as EC 1.6.2.1, transferred 1965 to EC 1.6.99.3]


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