IUBMB Enzyme Nomenclature


Accepted name: trypanothione-disulfide reductase

Reaction: trypanothione + NADP+ = trypanothione disulfide + NADPH + H+

For diagram click here.

Glossary: spermidine

Other name(s): trypanothione reductase; NADPH2:trypanothione oxidoreductase

Systematic name: trypanothione:NADP+ oxidoreductase

Comments: Trypanothione disulfide is the oxidized form of N1,N6-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC, glutathione-disulfide reductase)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 102210-35-5


1. Shames, S.L., Fairlamb, A.H., Cerami, A. and Walsh, C.T. Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases. Biochemistry 25 (1986) 3519-3526.

2. Marsh, I.R. and Bradley, M. Substrate specificity of trypanothione reductase. Eur. J. Biochem. 243 (1977) 690-694. [PMID: 9057833]

3. Cunningham, M.L. and Fairlamb, A.H. Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials. Eur. J. Biochem. 230 (1995) 460-468. [PMID: 7607216]

[EC created 1989 as EC, transferred 2002 to EC]

Return to EC 1.8.1 home page
Return to EC 1.8 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page