IUBMB Enzyme Nomenclature


Accepted name: protein-disulfide reductase (glutathione)

Reaction: 2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol

Other name(s): glutathione-insulin transhydrogenase; insulin reductase; reductase, protein disulfide (glutathione); protein disulfide transhydrogenase; glutathione-protein disulfide oxidoreductase; protein disulfide reductase (glutathione); GSH-insulin transhydrogenase; protein-disulfide interchange enzyme; protein-disulfide isomerase/oxidoreductase; thiol:protein-disulfide oxidoreductase; thiol-protein disulphide oxidoreductase

Systematic name: glutathione:protein-disulfide oxidoreductase

Comments: Reduces insulin and some other proteins.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9082-53-5


1. Katzen, H.M., Tietze, F. and Stetten, D. Further studies on the properties of hepatic glutathione-insulin transhydrogenase J. Biol. Chem. 238 (1963) 1006-1011.

2. Kohnert, K.-D., Hahn, H.-J., Zühlke, H., Schmidt, S. and Fiedler, H. Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro. Biochim. Biophys. Acta 338 (1974) 68-77.

[EC created 1965]

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