EC 2.1.1.124

Reaction: S-adenosyl-L-methionine + [cytochrome c]-arginine = S-adenosyl-L-homocysteine + [cytochrome c]-N^ω-methyl-arginine

Systematic name: S-adenosyl-L-methionine:[cytochrome c]-arginine N^ω-methyltransferase

Comments: the enzyme from Euglena gracilis methylates Arg-38 of horse heart cytochrome c to form the N^ω-monomethyl-arginine derivative. This enzyme was previously listed together with EC 2.1.1.25 phenol O-methyltransferase and EC 2.1.1.26 iodophenol O-methyltransferase as a single, now deleted, entry: Protein-arginine N-methyltransferase (EC 2.1.1.23).

Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 9055-07-6

References:

1. Farooqui, J.Z., Tuck, M., Paik, W.K. Purification and characterization of enzymes from Euglena gracilis that methylate methionine and arginine residues of cytochrome c. J. Biol. Chem. 260 (1985) 537-545. [PMID: 2981218]