Reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2
For diagram click here and mechanism here.
Other name(s): precorrin-6 methyltransferase; precorrin-6Y methylase
Systematic name: S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)
Comments: the enzyme from Pseudomonas denitrificans has S-adenosyl-L-methionine-dependent methyltransferase and decarboxylase activities.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 162995-22-4
References:
1. Blanche, F., Famechon, A., Thibaut, D., Debussche, L., Cameron, B., Crouzet, J. Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6Y to precorrin-8X is catalyzed by the cobL gene product. J. Bacteriol. 174 (1992) 1050-1052. [PMID: 1732195]