IUBMB Enzyme Nomenclature


Accepted name: 3'-demethylstaurosporine O-methyltransferase

Reaction: S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine

Other name(s): 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase; staurosporine synthase

Systematic name: S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase

Comments: Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 212906-74-6


1. Weidner, S., Kittelmann, M., Goeke, K., Ghisalba, O. and Zahner, H. 3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine. J. Antibiot. (Tokyo) 51 (1998) 679-682. [PMID: 9727395]

[EC created 2000]

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