IUBMB Enzyme Nomenclature


Accepted name: kaempferol 4'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + kaempferide

For diagram click here.

Glossary: kaempferide = 3,5,7-trihydroxy-4'-methoxyflavone

Other name(s): S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase; F 4'-OMT

Systematic name: S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase

Comments: The enzyme acts on the hydroxy group in the 4'-position of some flavones, flavanones and isoflavones. Kaempferol, apigenin and kaempferol triglucoside are substrates, as is genistein, which reacts more slowly. Compounds with an hydroxy group in the 3' and 4' positions, such as quercetin and eriodictyol, do not act as substrates. Similar to EC, apigenin 4'-O-methyltransferase and EC, 3,7-dimethylquercetin 4'-O-methyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 80747-20-2


1. Curir, P., Lanzotti, V., Dolci, M., Dolci, P., Pasini, C. and Tollin, G. Purification and properties of a new S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase from carnation (Dianthus caryophyllus L.). Eur. J. Biochem. 270 (2003) 3422-3431. [PMID: 12899699]

[EC created 2004]

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