IUBMB Enzyme Nomenclature


Accepted name: 23S rRNA (guanine2445-N2)-methyltransferase

Reaction: S-adenosyl-L-methionine + guanine2445 in 23S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA

Other name(s): ycbY (gene name); rlmL (gene name)

Systematic name: S-adenosyl-L-methionine:23S rRNA (guanine2445-N2)-methyltransferase

Comments: The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [1]. The enzyme specifically methylates guanine2445 at N2 in 23S rRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Lesnyak, D.V., Sergiev, P.V., Bogdanov, A.A. and Dontsova, O.A. Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. J. Mol. Biol. 364 (2006) 20-25. [PMID: 17010378]

[EC created 1976 as EC, part transferred 2010 to EC]

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