IUBMB Enzyme Nomenclature


Accepted name: 16S rRNA (cytidine1402-N4)-methyltransferase

Reaction: S-adenosyl-L-methionine + cytidine1402 in 16S rRNA = S-adenosyl-L-homocysteine + N4-methylcytidine1402 in 16S rRNA

Other name(s): RsmH; MraW

Systematic name: S-adenosyl-L-methionine:16S rRNA (cytidine1402-N4)-methyltransferase

Comments: RsmH catalyses the N4-methylation of cytidine1402 and RsmI (EC catalyses the 2'-O-methylation of cytidine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Kimura, S. and Suzuki, T. Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA. Nucleic Acids Res. 38 (2010) 1341-1352. [PMID: 19965768]

[EC created 2010]

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