IUBMB Enzyme Nomenclature


Accepted name: tRNASer (uridine44-2'-O)-methyltransferase

Reaction: S-adenosyl-L-methionine + uridine44 in tRNASer = S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer

Other name(s): TRM44

Systematic name: S-adenosyl-L-methionine:tRNASer (uridine44-2'-O)-methyltransferase

Comments: The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kotelawala, L., Grayhack, E.J. and Phizicky, E.M. Identification of yeast tRNA Um44 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNASer species. RNA 14 (2008) 158-169. [PMID: 18025252]

[EC created 2011]

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