IUBMB Enzyme Nomenclature


Accepted name: phenylethanolamine N-methyltransferase

Reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine

For diagram click here.

Other name(s): noradrenaline N-methyltransferase; noradrenalin N-methyltransferase; norepinephrine methyltransferase; norepinephrine N-methyltransferase; phenethanolamine methyltransferase; phenethanolamine N-methyltransferase

Systematic name: S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase

Comments: Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9037-68-7


1. Axelrod, J. Purification and properties of phenylethanolamine-N-methyl transferase. J. Biol. Chem. 237 (1962) 1657-1660.

2. Connett, R.J. and Kirschner, N. Purification and properties of bovine phenylethanolamine N-methyltransferase. J. Biol. Chem. 245 (1970) 329-334. [PMID: 5412063]

[EC created 1972]

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