IUBMB Enzyme Nomenclature


Accepted name: flavone 3'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + 3'-hydroxyflavone = S-adenosyl-L-homocysteine + 3'-methoxyflavone

For diagram of reaction click here

Other name(s): o-dihydric phenol methyltransferase; luteolin methyltransferase; luteolin 3'-O-methyltransferase; o-diphenol m-O-methyltransferase; o-dihydric phenol meta-O-methyltransferase; S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase; quercetin 3'-O-methyltransferase

Systematic name: S-adenosyl-L-methionine:3'-hydroxyflavone 3'-O-methyltransferase

Comments: The enzyme prefers flavones with vicinal 3',4'-dihydroxyl groups.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37205-55-3


1. Ebel, J., Hahlbrock, K. and Grisebach, H. Purification and properties of an o-dihydricphenol meta-O-methyltransferase from cell suspension cultures of parsley and its relation to flavonoid biosynthesis. Biochim. Biophys. Acta 268 (1972) 313-326. [PMID: 5026305]

2. Muzac, I., Wang, J., Anzellotti, D., Zhang, H. and Ibrahim, R.K. Functional expression of an Arabidopsis cDNA clone encoding a flavonol 3'-O-methyltransferase and characterization of the gene product. Arch. Biochem. Biophys. 375 (2000) 385-388. [PMID: 10700397]

3. Poulton, J.E., Hahlbrock, K. and Grisebach, H. O-Methylation of flavonoid substrates by a partially purified enzyme from soybean cell suspension cultures. Arch. Biochem. Biophys. 180 (1977) 543-549. [PMID: 18099]

4. Kim, B.G., Lee, H.J., Park, Y., Lim, Y. and Ahn, J.H. Characterization of an O-methyltransferase from soybean. Plant Physiol. Biochem. 44 (2006) 236-241. [PMID: 16777424]

5. Lee, Y.J., Kim, B.G., Chong, Y., Lim, Y. and Ahn, J.H. Cation dependent O-methyltransferases from rice. Planta 227 (2008) 641-647. [PMID: 17943312]

[EC created 1976, modified 2011]

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