Reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
Other name(s): protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase
Systematic name: S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase
Comments: One of a group of enzymes methylating proteins; see also EC 18.104.22.168 [cytochrome-c]-lysine N-methyltransferase and EC 22.214.171.124 calmodulin-lysine N-methyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9055-08-7
1. Paik, W.K. and Kim, S. Solubilization and partial purification of protein methylase 3 from calf thymus nuclei. J. Biol. Chem. 245 (1970) 6010-6015. [PMID: 5484460]
2. Venkatesan, M. and McManus, I.R. Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum. Biochemistry 18 (1979) 5365-5371. [PMID: 391266]