EC 2.1.1.44

Reaction: S-adenosyl-L-methionine + N^α,N^α-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N^α,N^α,N^α-trimethyl-L-histidine

Other name(s): dimethylhistidine methyltransferase; histidine-α-N-methyltransferase

Systematic name: S-adenosyl-L-methionine:N^α,N^α-dimethyl-L-histidine N^α-methyltransferase

Comments: Methylhistidine and histidine can also act as methyl acceptors, with trimethylhistidine being formed in both cases.

Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 62213-53-0

References:

1. Ishikawa, Y. and Melville, D.B. The enzymatic α-N-methylation of histidine. J. Biol. Chem. 245 (1970) 5967-5973. [PMID: 5484456]