IUBMB Enzyme Nomenclature


Accepted name: isoflavone 4'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone

For diagram of reaction click here or click here

Other name(s): 4'-hydroxyisoflavone methyltransferase; isoflavone methyltransferase; isoflavone O-methyltransferase

Systematic name: S-adenosyl-L-methionine:4'-hydroxyisoflavone 4'-O-methyltransferase

Comments: Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 55071-80-2


1. Wengenmayer, H., Ebel, J. and Grisebach, H. Purification and properties of a S-adenosylmethionine: isoflavone 4'-O-methyltransferase from cell suspension cultures of Cicer arietinum L. Eur. J. Biochem. 50 (1974) 135-143. [PMID: 4452353]

[EC created 1976, modified 2011]

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