IUBMB Enzyme Nomenclature


Accepted name: deoxycytidylate C-methyltransferase

Reaction: 5,10-methylenetetrahydrofolate + dCMP = dihydrofolate + deoxy-5-methylcytidylate

Other name(s): deoxycytidylate methyltransferase; dCMP methyltransferase

Systematic name: 5,10-methylenetetrahydrofolate:dCMP C-methyltransferase

Comments: dCMP is methylated by formaldehyde in the presence of tetrahydrofolate. CMP, dCTP and CTP can act as acceptors, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 61970-01-2


1. Kuo, T.-T. and Tu, J. Enzymatic synthesis of deoxy-5-methyl-cytidylic acid replacing deoxycytidylic acid in Xanthomonas oryzae phage Xp12DNA. Nature 263 (1976) 615. [PMID: 980110]

[EC created 1978]

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