Reaction: S-adenosyl-L-methionine + m7G5'ppp5'R-mRNA = S-adenosyl-L-homocysteine + m7G5'ppp5'Rm-mRNA
Other name(s): messenger ribonucleate nucleoside 2'-methyltransferase; messenger RNA (nucleoside-2'-)-methyltransferase
Systematic name: S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase
Comments: The nucleoside next to the terminal guanosine may be either guanosine or adenosine. The formation of a 2'-O-methyladenosine cap was formerly listed as EC 2.1.1.58.
Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 61970-02-3
References:
1. Barbosa, E. and Moss, B. mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Purification and physical properties. J. Biol. Chem. 253 (1978) 7692-7697. [PMID: 701281]
2. Barbosa, E. and Moss, B. mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity. J. Biol. Chem. 253 (1978) 7698-7702. [PMID: 701282]
3. Boone, R.F., Ensinger, M.J. and Moss, B. Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus. J. Virol. 21 (1977) 475-483. [PMID: 833934]
4. Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. Proc. Natl. Acad. Sci. USA 72 (1975) 2525-2529. [PMID: 1058472]
5. Groner, Y., Gilbao, E. and Aviv, H. Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. Biochemistry 17 (1978) 977-982. [PMID: 629955]