IUBMB Enzyme Nomenclature


Accepted name: [cytochrome c]-lysine N-methyltransferase

Reaction: S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine

Other name(s): cytochrome c (lysine) methyltransferase; cytochrome c methyltransferase; cytochrome c-specific protein methylase III; cytochrome c-specific protein-lysine methyltransferase

Systematic name: S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase

Comments: One of a group of enzymes methylating proteins; see also EC histone-lysine N-methyltransferase and EC calmodulin-lysine N-methyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 82047-78-7


1. Durban, E., Nochumson, S., Kim, S. and Paik, W.K. Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements. J. Biol. Chem. 253 (1978) 1427-1435. [PMID: 203592]

2. Nochumson, S., Durban, E., Sangduk, K. and Paik, W.K. Cytochrome c-specific protein methylase III from Neurospora crassa. Biochem. J. 165 (1977) 11-18. [PMID: 196592]

3. Valentine, J. and Pettigrew, G.W. A cytochrome c methyltransferase from Crithidia oncopelti. Biochem. J. 201 (1982) 329-338. [PMID: 6282265]

[EC created 1982, modified 1983]

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