IUBMB Enzyme Nomenclature


Accepted name: catechol O-methyltransferase

Reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

Other name(s): COMT I ; COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase

Systematic name: S-adenosyl-L-methionine:catechol O-methyltransferase

Comments: The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9012-25-3


1. Axelrod, J. and Tomchick, R. Enzymatic O-methylation of epinephrine and other catechols. J. Biol. Chem. 233 (1958) 702-705.

2. Gulliver, P.A. and Tipton, K.F. The purification and properties of pig brain catechol-O-methyltransferase. J. Neurochem. 32 (1979) 1525-1529. [PMID: 438821]

3. Huh, M.M.O. and Friedhof, A.J. Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization. J. Biol. Chem. 254 (1979) 299-308. [PMID: 762061]

[EC created 1965]

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