IUBMB Enzyme Nomenclature


Accepted name: tetrahydromethanopterin S-methyltransferase

Reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate

For diagram of reaction click here

coenzyme M (CoM) = 2-mercaptoethanesulfonate

Other name(s): tetrahydromethanopterin methyltransferase

Systematic name: 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase

Comments: Involved in the formation of methane from CO in Methanobacterium thermoautotrophicum. Methanopterin is a pterin analogue. The reaction involves the export of one or two sodium ions in Archaea.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 103406-60-6


1. Sauer, F.D. Tetrahydromethanopterin methyltransferase, a component of the methane synthesizing complex of Methanobacterium thermoautotrophicum. Biochem. Biophys. Res. Commun. 136 (1986) 542-547. [PMID: 3085670]

[EC created 1989, modified 2000]

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