IUBMB Enzyme Nomenclature


Accepted name: 8-hydroxyquercetin 8-O-methyltransferase

Reaction: S-adenosyl-L-methionine + 3,5,7,8,3',4'-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8-methoxyflavone

Other name(s): flavonol 8-O-methyltransferase; flavonol 8-methyltransferase; S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase; 8-hydroxyquercetin 8-O-methyltransferase [mis-spelt]

Systematic name: S-adenosyl-L-methionine:3,5,7,8,3',4'-hexahydroxyflavone 8-O-methyltransferase

Comments: Also acts on 8-hydroxykaempferol, but not on the glycosides of 8-hydroxyflavonols. An enzyme from the flower buds of Lotus corniculatus.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 99775-17-4


1. Jay, M., De Luca, V. and Ibrahim, R.K. Purification, properties and kinetic mechanism of flavonol 8-O-methyltransferase from Lotus corniculatus L. Eur. J. Biochem. 153 (1985) 321-325. [PMID: 4076180]

[EC created 1989]

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