Reaction: methanol + 5-hydroxybenzimidazolylcobamide = Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O
Other name(s): methanol cobalamin methyltransferase; methanol:5-hydroxybenzimidazolylcobamide methyltransferase; MT 1
Systematic name: methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Comments: The enzyme from Methanosarcina barkeri contains three-four molecules of bound 5-hydroxybenzimidazolylcobamide that act as methyl acceptor. Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 86611-98-5
References:
1. van der Meijden, P., te Brömmelstroet, B.W., Poirot, C.M., van der Drift, C. and Vogels, G.D. Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri. J. Bacteriol. 160 (1984) 629-635. [PMID: 6438059]