IUBMB Enzyme Nomenclature


Accepted name: N-acetylornithine carbamoyltransferase

Reaction: carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline

Glossary: N-acetyl-L-citrulline = N5-acetylcarbamoyl-L-ornithine

Other name(s): acetylornithine transcarbamylase; N-acetylornithine transcarbamylase; AOTC

Systematic name: carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase

Comments: Differs from EC, ornithine carbamoyltransferase. This enzyme replaces EC in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 890853-54-0


1. Shi, D., Morizono, H., Yu, X., Roth, L., Caldovic, L., Allewell, N.M., Malamy, M.H. and Tuchman, M. Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several Eubacteria. J. Biol. Chem. 280 (2005) 14366-14369. [PMID: 15731101]

2. Morizono, H., Cabrera-Luque, J., Shi, D., Gallegos, R., Yamaguchi, S., Yu, X., Allewell, N.M., Malamy, M.H. and Tuchman, M. Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis. J. Bacteriol. 188 (2006) 2974-2982. [PMID: 16585758]

[EC created 2005]

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