IUBMB Enzyme Nomenclature

EC 2.3.1.129

Accepted name: acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase

Reaction: an (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-α-D-glucosamine = an [acyl-carrier protein] + UDP-3-O-[(3R)-hydroxytetradecanoyl]-N-acetyl-α-D-glucosamine

Glossary: tetradecanoyl = myristoyl

Other name(s): UDP-N-acetylglucosamine acyltransferase; uridine diphosphoacetylglucosamine acyltransferase

Systematic name: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase

Comments: Involved with EC 2.4.1.182 (lipid-A-disaccharide synthase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, Lipid A, in the outer membrane of Escherichia coli.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 105843-69-4

References:

1. Anderson, M.S., Bulawa, C.E. and Raetz, C.R.H. The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli. J. Biol. Chem. 260 (1985) 15536-15541. [PMID: 3905795]

[EC 2.3.1.129 created 1990]


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