IUBMB Enzyme Nomenclature

EC 2.3.1.136

Accepted name: polysialic-acid O-acetyltransferase

Reaction: acetyl-CoA + an α-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9

Systematic name: acetyl-CoA:polysialic-acid O-acetyltransferase

Comments: Acts only on substrates containing more than 14 sialosyl residues. Catalyses the modification of capsular polysaccharides in some strains of Escherichia coli.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 116412-21-6

References:

1. Higa, H.H. and Varki, A. Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme responsible for the O-acetyl plus phenotype and for O-acetyl form variation. J. Biol. Chem. 263 (1988) 8872-8878. [PMID: 2897964]

[EC 2.3.1.136 created 1992]


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