IUBMB Enzyme Nomenclature


Accepted name: CO-methylating acetyl-CoA synthase

Reaction: acetyl-CoA + corrinoid protein = CoA + CO + methylcorrinoid protein

Systematic name: acetyl-CoA:corrinoid protein O-acetyltransferase

Comments: Contains nickel, copper and iron-sulfur clusters. Also catalyses exchange reactions of carbon between C-1 of acetyl-CoA and CO, and between C-2 of acetyl-CoA and methyl corrinoid protein. Involved, together with EC, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2. To follow its stoichiometry, the reaction can be written as:

CH3-CO-S-CoA + protein Co+ + H+ = CO + protein Co2+-CH3 + HS-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 176591-19-8


1. Ragsdale, S.W. and Wood, H.G. Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis. J. Biol. Chem. 260 (1985) 3970-3977. [PMID: 2984190]

2. Doukov, T.I., Iverson, T., Seravalli, J., Ragsdale, S.W. and Drennan, C.L. A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Science 298 (2002) 567-572. [PMID: 12386327]

[EC created 2003]

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