IUBMB Enzyme Nomenclature

EC 2.3.1.20

Accepted name: diacylglycerol O-acyltransferase

Reaction: acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol

Other name(s): diglyceride acyltransferase; 1,2-diacylglycerol acyltransferase; diacylglycerol acyltransferase; diglyceride O-acyltransferase; palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase; acyl-CoA:1,2-diacylglycerol O-acyltransferase

Systematic name: acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

Comments: Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9029-98-5

References:

1. Coleman, R. and Bell, R.M. Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols. J. Biol. Chem. 251 (1976) 4537-4543. [PMID: 947894]

2. Grigor, M.R. and Bell, R.M. Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis. Biochim. Biophys. Acta 712 (1982) 464-472. [PMID: 6289909]

3. Kawasaki, T. and Snyder, F. Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. J. Biol. Chem. 263 (1988) 2593-2596. [PMID: 3422635]

4. Weiss, S.B., Kennedy, E.P. and Kiyasu, J.Y. The enzymatic synthesis of triglycerides. J. Biol. Chem. 235 (1960) 40-44.

[EC 2.3.1.20 created 1965]


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