IUBMB Enzyme Nomenclature


Accepted name: benzalacetone synthase

Reaction: 4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2

For diagram of reaction click here.

Glossary: 4-hydroxybenzalacetone = 4-(4-hydroxyphenyl)but-3-en-2-one

Other name(s): BAS

Systematic name: 4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (4-hydroxybenzalacetone-forming)

Comments: A polyketide synthase that catalyses the C6-C4 skeleton of phenylbutanoids in higher plants.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Borejsza-Wysocki, W. and Hrazdina, G. Aromatic polyketide synthases (purification, characterization, and antibody development to benzalacetone synthase from raspberry fruits). Plant Physiol. 110 (1996) 791-799. [PMID: 12226219]

2. Abe, I., Takahashi, Y., Morita, H. and Noguchi, H. Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum. Eur. J. Biochem. 268 (2001) 3354-3359. [PMID: 11389739]

3. Zheng, D. and Hrazdina, G. Molecular and biochemical characterization of benzalacetone synthase and chalcone synthase genes and their proteins from raspberry (Rubus idaeus L.). Arch. Biochem. Biophys. 470 (2008) 139-145. [PMID: 18068110]

4. Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T. and Abe, I. A structure-based mechanism for benzalacetone synthase from Rheum palmatum. Proc. Natl. Acad. Sci. USA 107 (2010) 669-673. [PMID: 20080733]

[EC created 2013]

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