Reaction: acyl-CoA + cholesterol = CoA + cholesterol ester
Other name(s): cholesterol acyltransferase; sterol-ester synthase; sterol-ester synthetase; sterol-ester synthase; acyl coenzyme A-cholesterol-O-acyltransferase; acyl-CoA:cholesterol acyltransferase; ACAT; acylcoenzyme A:cholesterol O-acyltransferase; cholesterol ester synthase; cholesterol ester synthetase; cholesteryl ester synthetase
Systematic name: acyl-CoA:cholesterol O-acyltransferase
Comments: The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9027-63-8
1. Sgoutas, D.S. Effect of geometry and position of ethylenic bond upon acyl coenzymeA--cholesterol-O-acyltransferase. Biochemistry 9 (1970) 1826-1833. [PMID: 5439042]
2. Spector, A.A., Mathur, S.N. and Kaduce, T.L. Role of acylcoenzyme A: cholesterol O-acyltransferase in cholesterol metabolism. Prog. Lipid Res. 18 (1979) 31-53. [PMID: 42927]
3. Taketani, S., Nishino, T. and Katsuki, H. Characterization of sterol-ester synthetase in Saccharomyces cerevisiae. Biochim. Biophys. Acta 575 (1979) 148-155. [PMID: 389289]