IUBMB Enzyme Nomenclature


Accepted name: phosphatidylcholine—sterol O-acyltransferase

Reaction: phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester

Other name(s): lecithin—cholesterol acyltransferase; phospholipid—cholesterol acyltransferase; LCAT (lecithin-cholesterol acyltransferase); lecithin:cholesterol acyltransferase; lysolecithin acyltransferase

Systematic name: phosphatidylcholine:sterol O-acyltransferase

Comments: Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC phospholipase A2 and EC lysophospholipase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9031-14-5


1. Bartlett, K., Keat, M.J. and Mercer, E.I. Biosynthesis of sterol esters in Phycomyces blakesleeanus. Phytochemistry 13 (1974) 1107-1113.

2. Buckley, J.T., Halasa, L.N. and Macintyre, S. Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase. J. Biol. Chem. 257 (1982) 3320-3325. [PMID: 7061477]

3. Glomset, J.A.J. The plasma lecithins:cholesterol acyltransferase reaction. Lipid Res. 9 (1968) 155-167. [PMID: 4868699]

4. Vahouny, G.V. and Tradwell, C.R. Enzymatic synthesis and hydrolysis of cholesterol esters. Methods Biochem. Anal. 16 (1968) 219-272. [PMID: 4877146]

[EC created 1972, modified 1976]

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