IUBMB Enzyme Nomenclature

EC 2.3.1.59

Accepted name: gentamicin 2'-N-acetyltransferase

Reaction: acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a

Glossary: kanamycin

Other name(s): gentamycin acetyltransferase II; acetyl-CoA:gentamycin-C1a N2'-acetyltransferase; gentamycin 2'-N-acetyltransferase; acetyl-CoA:gentamycin-C1a N2'-acetyltransferase

Systematic name: acetyl-CoA:gentamicin-C1a N2'-acetyltransferase

Comments: The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 50864-40-9

References:

1. Benveniste, R. and Davies, J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc. Natl. Acad. Sci. USA 70 (1973) 2276-2280. [PMID: 4209515]

[EC 2.3.1.59 created 1976]


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