IUBMB Enzyme Nomenclature


Accepted name: choline O-acetyltransferase

Reaction: acetyl-CoA + choline = CoA + O-acetylcholine

Other name(s): choline acetylase; choline acetyltransferase

Systematic name: acetyl-CoA:choline O-acetyltransferase

Comments: Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9012-78-6


1. Berman, R., Wilson, I.B. and Nachmansohn, D. Choline acetylase specificity in relation to biological function. Biochim. Biophys. Acta 12 (1953) 315-324.

2. Berry, J.F. and Whittaker, V.P. The acyl-group specificity of choline acetylase. Biochem. J. 73 (1959) 447-458.

3. Fritz, I.B. and Schultz, S.K. Carnitine acetyltransferase. II. Inhibition by carnitine analogues and by sulfhydryl reagents. J. Biol. Chem. 240 (1965) 2188-2192.

4. Schuberth, J. Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction. Biochim. Biophys. Acta 122 (1966) 470-481.

[EC created 1961]

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