Reaction: choloyl-CoA + glycine = CoA + glycocholate
For diagram click here.
Other name(s): glycinetaurine N-acyltransferase; amino acid N-choloyltransferase; BAT; glycine N-choloyltransferase; BACAT; cholyl-CoA glycine-taurine N-acyltransferase; cholyl-CoA:taurine N-acyltransferase
Systematic name: choloyl-CoA:glycine N-choloyltransferase
Comments: Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-β-alanine can act as substrates, but more slowly . The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase . Bile-acidamino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol . This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 22.214.171.124, cholateCoA ligase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 65979-40-0
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