IUBMB Enzyme Nomenclature

EC 2.3.1.78

Accepted name: heparan-α-glucosaminide N-acetyltransferase

Reaction: acetyl-CoA + heparan sulfate α-D-glucosaminide = CoA + heparan sulfate N-acetyl-α-D-glucosaminide

Other name(s): acetyl-CoA:α-glucosaminide N-acetyltransferase

Systematic name: acetyl-CoA:heparan-α-D-glucosaminide N-acetyltransferase

Comments: Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed. Also acts on heparin. Not identical with EC 2.3.1.3 glucosamine N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate N-acetyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 79955-83-2

References:

1. Klein, V., Kresse, H. and von Figura, K. Sanfilippo syndrome type C: deficiency of acetyl-CoA:α-glucosaminide N-acetyltransferase in skin fibroblasts. Proc. Natl. Acad. Sci. USA 75 (1978) 5185-5189. [PMID: 33384]

2. Pohlmann, R., Klein, U., Fromme, H.G. and von Figura, K. Localisation of acetyl-CoA: α-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver. Hoppe-Seyler's Z. Physiol. Chem. 362 (1981) 1199-1207. [PMID: 7346380]

[EC 2.3.1.78 created 1984]


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