IUBMB Enzyme Nomenclature


Accepted name: aminoglycoside N3'-acetyltransferase

Reaction: acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3'-acetyl-2-deoxystreptamine antibiotic

Glossary: kanamycin

Other name(s): 3'-aminoglycoside acetyltransferase; 3-N-aminoglycoside acetyltransferase

Systematic name: acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase

Comments: Different from EC gentamicin 3'-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 60120-42-5


1. Davies, J. and O'Connor, S. Enzymatic modification of aminoglycoside antibiotics: 3-N-Acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin. Antimicrob. Agents Chemother. 14 (1978) 69-72. [PMID: 356726]

[EC created 1984]

Return to EC 2.3.1 home page
Return to EC 2.3 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page