IUBMB Enzyme Nomenclature

EC 2.3.1.81

Accepted name: aminoglycoside N3'-acetyltransferase

Reaction: acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3'-acetyl-2-deoxystreptamine antibiotic

Glossary: kanamycin

Other name(s): 3'-aminoglycoside acetyltransferase; 3-N-aminoglycoside acetyltransferase

Systematic name: acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase

Comments: Different from EC 2.3.1.60 gentamicin 3'-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 60120-42-5

References:

1. Davies, J. and O'Connor, S. Enzymatic modification of aminoglycoside antibiotics: 3-N-Acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin. Antimicrob. Agents Chemother. 14 (1978) 69-72. [PMID: 356726]

[EC 2.3.1.81 created 1984]


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