IUBMB Enzyme Nomenclature


Accepted name: peptide α-N-acetyltransferase

Reaction: acetyl-CoA + peptide = CoA + Nα-acetylpeptide

Other name(s): β-endorphin acetyltransferase; peptide acetyltransferase; protein N-terminal acetyltransferase; NAT; Nα-acetyltransferase; amino-terminal amino acid-acetylating enzyme

Systematic name: acetyl-CoA:peptide Nα-acetyltransferase

Comments: Acetylates N-terminal alanine, serine, methionine and glutamate residues in a number of peptides and proteins, including β-endorphin, corticotropins and melanotropin. cf. EC α-tubulin N-acetyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 83452-29-3


1. Driessen, H.P.C., Tesser, G.I. and Bloemendal, H. The mechanism of N-terminal acetylation of proteins. CRC Crit. Rev. Biochem. 18 (1985) 281. [PMID: 3902358]

2. Glembotski, C.C. Characterization of the peptide acetyltransferase activity in bovine and rat intermediate pituitaries responsible for the acetylation of β-endorphin and α-melanotropin. J. Biol. Chem. 257 (1982) 10501-10509. [PMID: 6286657]

3. O'Donohue, T.L. Identification of endorphin acetyltransferase in rat brain and pituitary gland. J. Biol. Chem. 258 (1983) 2163-2167. [PMID: 6296134]

4. Tsunasawa, S., Kamitani, K. and Norita, K. Partial purification and properties of the amino-terminal amino acid-acetylating enzyme from hen's oviduct. J. Biochem. (Tokyo) 87 (1980) 645-650. [PMID: 6244269]

[EC created 1986, modified 1989]

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