IUBMB Enzyme Nomenclature


Accepted name: 2-hydroxyglutarate synthase

Reaction: propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA

Other name(s): 2-hydroxyglutaratic synthetase; 2-hydroxyglutaric synthetase; α-hydroxyglutarate synthase; hydroxyglutarate synthase; 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating)

Systematic name: propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9024-02-6


1. Reeves, H.C. and Ajl, S.J. α-Hydroxyglutaric acid synthetase. J. Bacteriol. 84 (1962) 186-187.

[EC created 1965 as EC, transferred 2002 to EC]

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