IUBMB Enzyme Nomenclature


Accepted name: 2-ethylmalate synthase

Reaction: acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA

For diagram click here.

Other name(s): (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating); 2-ethylmalate-3-hydroxybutanedioate synthase; propylmalate synthase; propylmalic synthase

Systematic name: acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)

Comments: Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 3-ethylmalate synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9024-01-5


1. Strassman, M. and Ceci, L.N. A study of acetyl-CoA condensation with α-keto acids. Arch. Biochem. Biophys. 119 (1967) 420-428. [PMID: 6052435]

[EC created 1983 as EC, transferred 2002 to EC]

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