Reaction: acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA
For diagram click here.
Other name(s): (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating); 2-ethylmalate-3-hydroxybutanedioate synthase; propylmalate synthase; propylmalic synthase
Systematic name: acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Comments: Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 188.8.131.52 3-ethylmalate synthase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9024-01-5
1. Strassman, M. and Ceci, L.N. A study of acetyl-CoA condensation with α-keto acids. Arch. Biochem. Biophys. 119 (1967) 420-428. [PMID: 6052435]