IUBMB Enzyme Nomenclature

EC 2.4.1.109

Accepted name: dolichyl-phosphate-mannose—protein mannosyltransferase

Reaction: dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein

For diagram of reaction click here.

Other name(s): dolichol phosphomannose-protein mannosyltransferase; protein O-D-mannosyltransferase; dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase

Systematic name: dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase

Comments: The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain α-dihydropolyprenyl derivatives, larger than C35.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 74315-99-4

References:

1. Babczinski, P., Haselbeck, A. and Tanner, W. Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. Eur. J. Biochem. 105 (1980) 509-515. [PMID: 6989607]

2. Palamarczyk, G., Lehle, L., Mankowski, T., Chojnacki, T. and Tanner, W. Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives. Eur. J. Biochem. 105 (1980) 517-523. [PMID: 6445267]

[EC 2.4.1.109 created 1983, modified 2014]


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