IUBMB Enzyme Nomenclature

EC 2.4.1.164

Accepted name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide β-1,6-N-acetylglucosaminyltransferase

Reaction: UDP-N-acetyl-D-glucosamine + D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-(1→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosylceramide

For diagram of reaction click here.

Other name(s): uridine diphosphoacetylglucosamine-acetyllactosaminide β1→6-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-β-D-glucosaminyl-1,3-β-D-galactosyl-1,4-β-D-glucosylceramide β-1,6-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl(1↔1)ceramide 6-β-N-acetylglucosaminyltransferase

Systematic name: UDP-N-acetyl-D-glucosamine:D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide 6-β-N-acetylglucosaminyltransferase

Comments: Requires Mn2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 85638-40-0

References:

1. Basu, M. and Basu, S. Biosynthesis in vitro of Ii core glycosphingolipids from neolactotetraosylceramide by β1-3- and β1-6-N-acetylglucosaminyltransferases from mouse T-lymphoma. J. Biol. Chem. 259 (1984) 12557-12562. [PMID: 6238026]

[EC 2.4.1.164 created 1989]


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