IUBMB Enzyme Nomenclature


Accepted name: lipid-A-disaccharide synthase

Reaction: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine + 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl-(1→6)-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl 1-phosphate

For diagram of reaction click here.

Other name(s): UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-β-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase (incorrect)

Systematic name: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl-1-phosphate 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-D-glucosaminyltransferase

Comments: Involved with EC (acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase) and EC (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 105843-81-0


1. Crowell, D.N., Reznikoff, W.S. and Raetz, C.R.H. Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase. J. Bacteriol. 169 (1987) 5727-5734. [PMID: 2824445]

2. Ray, B.L., Painter, G. and Raetz, C.R.H. The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli. J. Biol. Chem. 259 (1984) 4852-4859.

[EC created 1990]

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