IUBMB Enzyme Nomenclature

EC 2.4.1.45

Accepted name: 2-hydroxyacylsphingosine 1-β-galactosyltransferase

Reaction: UDP-α-D-galactose + a 2-(2-hydroxyacyl)sphingosine = UDP + a 1-(β-D-galactosyl)-2-(2-hydroxyacyl)sphingosine

Other name(s): uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase; UDP-galactose-2-hydroxyacylsphingosine galactosyltransferase; UDP-galactose:ceramide galactosyltransferase; UDP-galactose:2-2-hydroxyacylsphingosine galactosyltransferase; UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-β-D-galactosyl-transferase

Systematic name: UDP-α-D-galactose:2-(2-hydroxyacyl)sphingosine 1-β-D-galactosyl-transferase

Comments: Highly specific.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37277-54-6

References:

1. Basu, S., Schultz, A., Basu, M. and Roseman, S. Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain. J. Biol. Chem. 243 (1971) 4272-4279. [PMID: 5090043]

2. Morell, P. and Radin, N.S. Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid. Biochemistry 8 (1969) 506-512. [PMID: 5793706]

[EC 2.4.1.45 created 1972]


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