IUBMB Enzyme Nomenclature

EC 2.4.1.50

Accepted name: procollagen galactosyltransferase

Reaction: UDP-α-D-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine

Other name(s): hydroxylysine galactosyltransferase; collagen galactosyltransferase; collagen hydroxylysyl galactosyltransferase; UDP galactose-collagen galactosyltransferase; uridine diphosphogalactose-collagen galactosyltransferase; UDPgalactose:5-hydroxylysine-collagen galactosyltransferase; UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase

Systematic name: UDP-α-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase

Comments: Probably involved in the synthesis of carbohydrate units in complement (cf EC 2.4.1.66 procollagen glucosyltransferase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9028-07-3

References:

1. Bosmann, H.B. and Eylar, E.H. Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen. Biochem. Biophys. Res. Commun. 33 (1968) 340-346. [PMID: 5722225]

2. Kivirikko, K.I. and Myllyla, R. In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.

[EC 2.4.1.50 created 1972, modified 1983]


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