IUBMB Enzyme Nomenclature

EC 2.4.1.69

Accepted name: galactoside 2-α-L-fucosyltransferase

Reaction: GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide = GDP + α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide

For diagram of reaction click here.

Glossary: lactotetraosylceramide = β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide
III2-α-fucosyllactotetraosylceramide = α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide

Other name(s): blood group H α-2-fucosyltransferase; guanosine diphosphofucose-galactoside 2-L-fucosyltransferase; α-(1→2)-L-fucosyltransferase; α-2-fucosyltransferase; α-2-L-fucosyltransferase; blood-group substance H-dependent fucosyltransferase; guanosine diphosphofucose-glycoprotein 2-α-fucosyltransferase; guanosine diphosphofucose-lactose fucosyltransferase; GDP fucose-lactose fucosyltransferase; guanosine diphospho-L-fucose-lactose fucosyltransferase; guanosine diphosphofucose-β-D-galactosyl-α-2-L-fucosyltransferase; guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide α-L-fucosyltransferase; guanosine diphosphofucose-glycoprotein 2-α-L-fucosyltransferase; H-gene-encoded β-galactoside α1→2fucosyltransferase; secretor-type β-galactoside α1→2fucosyltransferase; β-galactoside α1→2fucosyltransferase; GDP-L-fucose:lactose fucosyltransferase; GDP-β-L-fucose:β-D-galactosyl-R 2-α-L-fucosyltransferase

Systematic name: GDP-β-L-fucose:β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide 2-α-L-fucosyltransferase

Comments: Free lactose can act as acceptor. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. The action on glycolipid was previously listed as EC 2.4.1.89.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 56093-23-3

References:

1. Basu, S., Basu, M. and Chien, J.L. Enzymatic synthesis of a blood group H-related glycosphingolipid by an α-fucosyltransferase from bovine spleen. J. Biol. Chem. 250 (1975) 2956-2962. [PMID: 804484]

2. Beyer, T.A. and Hill, R.L. Enzymatic properties of the β-galactoside α 1 leads to 2 fucosyltransferase from porcine submaxillary gland. J. Biol. Chem. 255 (1980) 5373-5379. [PMID: 7372640]

3. Beyer, T.A., Sadler, J.E. and Hill, R.L. Purification to homogeneity of H blood group β-galactoside α 1 leads to 2 fucosyltransferase from porcine submaxillary gland. J. Biol. Chem. 255 (1980) 5364-5372. [PMID: 6246105]

4. Grollman, A.P. GDP-L-fucose:lactose fucosyltransferase from mammary gland. Methods Enzymol. 8 (1966) 351-353.

[EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002]


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