IUBMB Enzyme Nomenclature

EC 2.4.1.80

Accepted name: ceramide glucosyltransferase

Reaction: UDP-glucose + an N-acylsphingosine = UDP + a D-glucosyl-N-acylsphingosine

For diagram of reaction click here.

Other name(s): UDP-glucose:ceramide glucosyltransferase; ceramide:UDPGlc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase

Systematic name: UDP-glucose:N-acylsphingosine D-glucosyltransferase

Comments: Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37237-44-8

References:

1. Basu, S., Kaufman, B. and Roseman, S. Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain. J. Biol. Chem. 248 (1973) 1388-1394. [PMID: 4631392]

[EC 2.4.1.80 created 1976]


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