IUBMB Enzyme Nomenclature

EC 2.4.2.19

Accepted name: nicotinate-nucleotide diphosphorylase (carboxylating)

Reaction: nicotinate β-D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-α-D-ribose 1-diphosphate

For diagram of reaction click here.

Other name(s): quinolinate phosphoribosyltransferase (decarboxylating); quinolinic acid phosphoribosyltransferase; QAPRTase; NAD+ pyrophosphorylase; nicotinate mononucleotide pyrophosphorylase (carboxylating); quinolinic phosphoribosyltransferase; nicotinate-D-ribonucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)

Systematic name: nicotinate-β-D-ribonucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)

Comments: This is the first enzyme that prokaryotes and eukaryotes have in common in the production of NAD+ as some prokaryotes use an L-aspartate pathway to produce quinolinate whereas all eukaryotes use tryptophan as the starting material [3].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37277-74-0

References:

1. Gholson, R.K., Ueda, I., Ogasawara, N. and Henderson, L.M. The enzymatic conversion of quinolinate to nicotinic acid mononucleotide in mammalian liver. J. Biol. Chem. 239 (1964) 1208-1214.

2. Packman, P.M. and Jakoby, W.B. Crystalline quinolinate phosphoribosyltransferase. J. Biol. Chem. 240 (1965) 4107-4108. [PMID: 5320648]

3. Katoh, A., Uenohara, K., Akita, M. and Hashimoto, T. Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid. Plant Physiol. 141 (2006) 851857. [PMID: 16698895]

[EC 2.4.2.19 created 1972]


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