Reaction: nicotinate β-D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-α-D-ribose 1-diphosphate
For diagram of reaction click here.
Other name(s): quinolinate phosphoribosyltransferase (decarboxylating); quinolinic acid phosphoribosyltransferase; QAPRTase; NAD+ pyrophosphorylase; nicotinate mononucleotide pyrophosphorylase (carboxylating); quinolinic phosphoribosyltransferase; nicotinate-D-ribonucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
Systematic name: nicotinate-β-D-ribonucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
Comments: This is the first enzyme that prokaryotes and eukaryotes have in common in the production of NAD+ as some prokaryotes use an L-aspartate pathway to produce quinolinate whereas all eukaryotes use tryptophan as the starting material .
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37277-74-0
1. Gholson, R.K., Ueda, I., Ogasawara, N. and Henderson, L.M. The enzymatic conversion of quinolinate to nicotinic acid mononucleotide in mammalian liver. J. Biol. Chem. 239 (1964) 1208-1214.
2. Packman, P.M. and Jakoby, W.B. Crystalline quinolinate phosphoribosyltransferase. J. Biol. Chem. 240 (1965) 4107-4108. [PMID: 5320648]
3. Katoh, A., Uenohara, K., Akita, M. and Hashimoto, T. Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid. Plant Physiol. 141 (2006) 851Ð857. [PMID: 16698895]