Reaction: a pyrimidine nucleoside + phosphate = a pyrimidine base + α-D-ribose 1-phosphate
Other name(s): Py-NPase
Systematic name: pyrimidine-nucleoside:phosphate α-D-ribosyltransferase
Comments: Both uridine and thymidine are substrates [3].
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9055-35-0
References:
1. Friedkin, M. and Kalckar, H. Nucleoside phosphorylases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 5, Academic Press, New York, 1961, p. 237-255.
2. Saunders, P.P., Wilson, B.A. and Saunders, G.F. Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus.J. Biol. Chem. 244 (1969) 3691-3697. [PMID: 4978445].
3. Hamamoto, T., Noguchi, T. and Midorikawa, Y. Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus TH 6-2. Biosci. Biotechnol. Biochem. 60 (1996) 1179-1180. [PMID: 8782414]