IUBMB Enzyme Nomenclature

EC 2.4.2.26

Accepted name: protein xylosyltransferase

Reaction: Transfers a β-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate

Other name(s): UDP-D-xylose:core protein β-D-xylosyltransferase; UDP-D-xylose:core protein xylosyltransferase; UDP-D-xylose:proteoglycan core protein β-D-xylosyltransferase; UDP-xylose-core protein β-D-xylosyltransferase; uridine diphosphoxylose-core protein β-xylosyltransferase; uridine diphosphoxylose-protein xylosyltransferase

For diagram click here.

Systematic name: UDP-D-xylose:protein β-D-xylosyltransferase

Comments: Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 55576-38-0

References:

1. Stoolmiller, A.C., Horwitz, A.L. and Dorfman, A. Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase. J. Biol. Chem. 247 (1972) 3525-3532. [PMID: 5030630]

2. Götting, C., Kuhn, J., Zahn, R., Brinkmann, T. and Kleesiek, K. Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein β-D-xylosyltransferase and its first isoform XT-II. J. Mol. Biol. 304 (2000) 517-528. [PMID: 11099377]

[EC 2.4.2.26 created 1976, modified 2002]


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