Reaction: S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-α-D-ribose 1-phosphate
For diagram click here.
Other name(s): 5'-methylthioadenosine nucleosidase; 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase
Systematic name: S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase
Comments: Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 61970-06-7
1. Carteni-Farina, M., Oliva, A., Romeo, G., Napolitano, G., De Rosa, M., Gambacorta, A. and Zappia, V. 5'-Methylthioadenosine phosphorylase from Caldariella acidophila. Purification and properties. Eur. J. Biochem. 101 (1979) 317-324. [PMID: 118001]
2. Garbers, D.L. Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung. Biochim. Biophys. Acta 523 (1978) 82-93. [PMID: 415762]
3. Pegg, A.E. and Williams-Ashman, H.G. Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate. Biochem. J. 115 (1969) 241-247. [PMID: 5378381]